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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Org Lett. 2009 Jan 1;11(1):9–12. doi: 10.1021/ol8022006

Table 1.

Optimization of Reaction Conditionsa

graphic file with name nihms-86656-t0006.jpg
Entry conditions α:βb
1 KHMDS, THF, −78 °C, allyl bromide 95:5
2 NaH, DMF, allyl bromide, 0 °C 1:1
3 NaH, DMF, LiBr, allyl bromide, 0 °C 1:1.5
4 NaH, dioxane, allyl bromide, 23 °C 5:95
a

Performed at 0.1 M.

b

As determined by 1H NMR (600 MHz)