Table 1.
Recent human studies investigating angiogenesis and vascular remodeling in COPD
| Investigator (year) | Tissue samples Sample size | Studied parameters |
|---|---|---|
| Kranenburg et al (2005) | Central and peripheral lung tissues 14 patients-14 controls | VEGF |
| FLT-1 | ||
| KDR/Flk-1 | ||
| Hashimoto et al (2005) | Lung specimens 11 patients-8 controls | VEGF |
| bFGF | ||
| Calabrese et al (2006) | Bronchial specimens 18 patients-8 controls | VEGF |
| Integrin αvβ3 | ||
| Santos et al (2003) | Lung specimens-pulmonary muscular arteries 19 nonsmokers-21 smokers-28 moderateCOPD-severe emphysema | VEGF |
| Peinado et al (2006) | Pulmonary arteries from lung specimens 9 COPD patients-6 controls | VEGF |
| VEGFR2 |