Table 2.
List of studied angiogenic and angiostatic mediators in COPD
| Systematic name | Previous name | Chemokine receptor | Activity |
|---|---|---|---|
| CXC Chemokines | |||
| CXCL1 | GRO-α | CXCR2>CXCR1 | angiogenic |
| CXCL5 | ENA-78 | CXCR2 | angiogenic |
| CXCL8 | IL-8 | CXCR2, CXCR1 | angiogenic |
| CXCL9 | MIG | CXCR3 | angiostatic |
| CXCL10 | IP-10 | CXCR3 | angiostatic |
| CXCL11 | I-TAC | CXCR3 | angiostatic |
| CC Chemokines | |||
| CCL2 | MCP-1/Eotaxin | CCR2 | angiogenic |
| Growth factors | |||
| VEGF | Flt-1, KDR/Flk-1 | angiogenic | |
| bFGF | FGFR-1 | angiogenic | |
| Angiopoietin-1 | Tie-2 | angiogenic | |
| HGF | angiogenic | ||
| EGF | angiogenic | ||