. 2007 Dec;2(4):541–550.

Table 1.

Linkage analysis: genomewide scans

Study	Population	Main results	LOD score^§
Framingham Heart Study (Joost et al 2002)	Healthy Subjects: 1578 members of 330 families	Chromosome 6: FEV₁	2.4
Framingham Heart Study (Joost et al 2002)	Healthy Subjects: 1578 members of 330 families	Chromosome 21: FVC	2.6
National Heart, Lung and Blood Institute Family Heart Study (Wilk et al 2003)	Healthy Subjects: 2178 members of 391 families	Chromosome 4: FEV₁/FVC	3.5
		Chromosome 18: FEV₁	2.5
		Chromosome 18: FVC	2.9
Boston Early-onset Study (Silverman et al 2002)	Patients with COPD + Pedigrees: 585 members of 72 families	Chromosome 2q: FEV₁/FVC	4.13
		Chromosome 12p: FEV₁	3.26^*
		Chromosome 19q: Chronic bronchitis	3.30^*
		Chromosome 12p: Airway Obstruction	3.14^*
Netherland Asthma Study (Postma et al 2005)	Patients with Asthma + Pedigrees: 200 families	Chromosome 2q: Pre- and postbronchodilator FEV₁%VC	4.9/6.03^**

^{^§}

LOD > 3 denotes significant evidence for linkage; LOD < 3 denotes suggestive evidence;

only smoker;

^**

pre- and postbronchodilator FEV₁%VC was obtained for chromosome 2q (2q32, LOD 4,9/6.03).