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. Author manuscript; available in PMC: 2009 Jun 22.
Published in final edited form as: Neurobiol Dis. 2007 May 5;27(2):207–219. doi: 10.1016/j.nbd.2007.04.009

Figure 4. Acquisition of reflex responses in SMNΔ7 SMA mice.

Figure 4

SMNΔ7 SMA mice (black bars) as well as their carrier (light grey bars) and normal (dark grey bars) littermates were assessed for the acquisition of various reflex responses and their latencies. Most of the SMNΔ7 SMA mice tested were unable to exhibit a surface righting response (A), response to negative geotaxis (C) or aversion to falling from a cliff (E) at all ages tested. As a result, the amount of time needed (latency) to exhibit the surface righting (B) and the negative geotaxis (D) response is significantly greater in SMNΔ7 SMA mice than in non-SMA (i.e., carrier or normal) mice. The success rates of carrier mice in acquiring the reflex responses tested as well as their latencies are the same as those of normal mice. Legend; *p < 0.05 for SMA vs. normal mice and vs. carrier mice.