Figure 3.

I/R-induced tissue KC and MCP-1 are augmented in MC3R-null mice. WT and MC3R-null mice were subjected to occlusion of the superior mesenteric artery for 35 min, followed by 90 min reperfusion. For either genotype, a sham-treatment group was also analyzed, where laparotomy was conducted with no occlusion of the artery. Mesenteries were homogenized and protein extracts were used for the ELISA assays to determine tissue content of MCP-1 (A) and KC (B). Data are means ± se; 6 mice/group. *P < 0.05 vs. respective sham-treatment group. ^#P < 0.05 between genotypes post-I/R.