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. Author manuscript; available in PMC: 2010 Jun 1.

Published in final edited form as: Int J Cancer. 2009 Jun 1;124(11):2634–2642. doi: 10.1002/ijc.24222

(a): Widefield fluorescence images of three oral specimens obtained pre- (left) and post- (right) labeling with 2-NBDG. The top specimen was clinically and histologically normal and the bottom two specimens were clinically abnormal and diagnosed as invasive cancer. (b): Mean fluorescence intensity calculated from pre- and post-contrast widefield images of intact biopsy specimens shown in (a). (c): Differential contrast measure based on the ratio of the increase in the mean fluorescence intensity of clinically abnormal epithelium to that of clinically normal epithelium from paired samples in 8 patients following labeling with 2-NBDG. Results are plotted as a function of histopathologic diagnosis. Scale bar represents 6.5 mm.

(a): Widefield fluorescence images of three oral specimens obtained pre- (left) and post- (right) labeling with 2-NBDG. The top specimen was clinically and histologically normal and the bottom two specimens were clinically abnormal and diagnosed as invasive cancer. (b): Mean fluorescence intensity calculated from pre- and post-contrast widefield images of intact biopsy specimens shown in (a). (c): Differential contrast measure based on the ratio of the increase in the mean fluorescence intensity of clinically abnormal epithelium to that of clinically normal epithelium from paired samples in 8 patients following labeling with 2-NBDG. Results are plotted as a function of histopathologic diagnosis. Scale bar represents 6.5 mm.