Figure 7. Surface expression of mLangerin as detected with L31 mAb.
DCs from BALB/c mice were enriched by negative selection. In brief, spleen and skin draining LN cell suspensions were incubated with biotin-labeled anti-CD3, B220, CD19, DX5, Gr1 and Thy1.2 mAbs. The non-DCs were removed by the application of a magnetic field after the incubation with streptavidin-beads. Cells were stained with Alexa 647 labeled L31 mAb, or the corresponded isotype control, and CD11c FITC. For the total staining, the cells were fixed and permeabilized with cytofix/cytoperm buffer (BD Biosciences) following the manufacture’s instructions.