Table 1.

Possible patient conditions and their corresponding actions from the guidelines

		Conditions					Actions
Profile #	Number of patients	Acute symptoms	HbA1c (%)	Ongoing type of treatment	BMI* (Kg/m2)	Renal insufficiency	Elderly	Type of treatment	Pharmaco-therapeutic class	International non proprietary name	Dose
1	2	Yes	Any	Any	Any	Any	Any	Insulin therapy	Insulin	NM***	NM***
2	16	No	≤ 6.5	Any	Any	Any	Any	The same as ongoing treatment	The same as ongoing treatment	The same as ongoing treatment	The same as ongoing treatment
3	7	No	Between 6.6 and 8	Diet and Exercise	Any	Any	Any	Evaluate risk-benefit of continuing or changing the treatment	NM***	NM***	NM***
4	51	No	Between 6.6 and 8	Monotherapy	Any	Any	Any	Evaluate risk-benefit versus of continuing or changing the treatment	NM***	NM***	NM***
5	59	No	Between 6.6 and 8	Bitherapy	Any	Any	Any	NM***	NM***	NM***	NM***
6	16	No	Between 6.6 and 8	Tritherapy	Any	Any	Any	NM***	NM***	NM***	NM***
7	84	No	Between 6.6 and 8	Insulin [+OAD]**	Any	Any	Any	NM***	NM***	NM***	NM***
8	2	No	>8	Diet and Exercise	Any, other than "BMI ≥ 28 and no renal insufficiency"		No	Monotherapy	Any	NM***	NM***
9	1	No	>8	Diet and Exercise	Any, other than "BMI ≥ 28 and no renal insufficiency"		Yes	Monotherapy	Any, other than long acting sulfonylurea	NM***	NM***
10	2	No	>8	Diet and Exercise	≥ 28	No	Any	Monotherapy	Biguanides	Metformine	NM***
11	24	No	>8	Oral monotherapy not at maximum dose	Any	Any	Any	Oral monotherapy	The same as ongoing treatment	NM***	Increase dose until reaching the maximum tolerated
12	1	No	>8	Oral monotherapy at maximum dose	Any	Any	Any	Oral bitherapy	NM***	NM***	NM***
13	39	No	>8	Oral bitherapy with any combination other than "Oral bitherapy with biguanides and sulfonylurea at maximum dose"	Any	Any	Any	Oral bitherapy	Biguanides and sulfonylurea	NM***	NM***
14	18	No	>8	Oral bitherapy with biguanides and sulfonylurea at maximum dose	Any	Any	Any	Insulin [+OAD]**	Insulin [+OAD]**	NM***	NM***
15	18	No	>8	Oral tritherapy	Any	Any	Any	NM***	NM***	NM***	NM***
16	123	No	>8	Insulin [+OAD]**	Any	Any	Any	NM***	NM***	NM***	NM***

* BMI: body mass index

** Insulin [+OAD]: insulin alone or with oral anti-diabetic drugs

*** NM: not mentioned in the guidelines