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. 2009 Jun 22;106(27):11288–11293. doi: 10.1073/pnas.0812931106

Fig. 3.

Fig. 3.

Peripheral and hepatic insulin responsiveness was assessed by using the hyperinsulinemic-euglycemic clamp. Basal endogenous glucose production was decreased with SirT1 ASO in the T2DM rat model (A). Overall glucose infusion rate was increased in SirT1 ASO in the T2DM rat model (B) that can be attributed to the decrease in clamp hepatic glucose production (C). Insulin-stimulated whole-body glucose metabolism (D), glucose uptake in the soleus (E), and white adipose tissue (F) was similar between groups. (n = 9–21 per group.) *, P < 0.05.