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SirT1 ASO increased acetylation of key transcription factors for gluconeogenesis. STAT3 acetylation (A) and phosphorylation (B) were increased by SirT1 ASO. Foxo1 acetylation (C) and PGC-1α (D) acetylation levels were also increased with SirT1 ASO. The increased acetylation led to a decrease in transcription of PEPCK (E), FBPase (F), G6Pase (G), and PEPCK protein (H). (n = 4–8 per group.) #, P < 0.1; *, P < 0.05.
