Table 1.
Metabolic profiles in control ASO and SirT1 ASO
| Metabolite and concentration | Normal chow |
T2DM rat model |
||
|---|---|---|---|---|
| Control ASO | SirT1 ASO | Control ASO | SirT1 ASO | |
| Plasma glucagon, pg/ml | n.d. | n.d. | 60.5 ± 4.6 | 56.5 ± 3.3 |
| Adiponectin, μg/ml | 2.8 ± 0.6 | 1.2 ± 0.2* | 2.9 ± 0.2 | 1.6 ± 0.2** |
| Leptin, ng/ml | 0.9 ± 0.2 | 0.3 ± 0.2* | 3.3 ± 0.5 | 1.4 ± 0.3* |
| Fatty acids, mEq/L | 0.79 ± 0.07 | 0.66 ± 0.06* | 0.85 ± 0.13 | 0.66 ± 0.08* |
| White adipose tissue, g | 1.8 ± 0.1 | 1.4 ± 0.1* | 3.1 ± 0.2 | 1.7 ± 0.2** |
| Plasma triglycerides, mg/dL | 22.5 ± 4.0 | 24.1 ± 3.9 | 31.4 ± 2.7 | 34.6 ± 2.7 |
| β-Hydroxybutyrate, mmol/L | 0.9 ± 0.1 | 0.9 ± 0.1 | 1.2 ± 0.1 | 0.9 ± 0.1* |
| Liver triglycerides, mg/g of tissue | n.d. | n.d. | 14.4 ± 1.2 | 11.8 ± 1.1 |
Data are presented as mean ± SEM (n = 6–19 per group); n.d., not determined.
*, P < 0.05;
**, P < 0.005; compared with control ASO