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. 2009 Jun 22;106(31):12849–12854. doi: 10.1073/pnas.0902281106

Fig. 5.

Fig. 5.

Hypothetical molecular model of DNA wrapping by UvrA and UvrB. (A) UvrA (olive; PDB ID code 2R6F) dimer first interacts with DNA, causing a slight bend. The DNA is expected to make major contact with the region shown in yellow. (B) UvrB (light blue; PDB ID code 2FDC) interacts with the domain of UvrA shown in gold, through domain 2 of UvrB (aqua). The β-hairpin is shown in blue, and the ribbon diagram is at the UvrA–DNA–UvrB interface. (C) The DNA is transferred from UvrA to the β-hairpin of UvrB, and the DNA becomes highly bent. (D) DNA wrapping is facilitated by UvrA around UvrB. (E) Full engagement of the DNA by UvrB helps to trigger the release of UvrA, leaving the fully wrapped DNA around UvrB.