Fig. 2.

Influence of the gut microbiota on myocardial substrate selection. Hearts from fasted WT GF or CONV-D animals were perfused for 60 min in the working mode by using Krebs–Henseleit buffer containing 1.7 mM β-hydroxybutyrate, 5 mM glucose, and 1.2 mM palmitate. (A) Oxidation of d-[¹⁴C(U)]-glucose; n = 5 animals per group. (B) Oxidation of [9,10]-³H-palmitate; n = 8 animals per group. (C) Oxidation of d-[¹⁴C(U)]-glucose in the absence of added β-hydroxybutyrate, n = 5 animals per group. *, P < 0.05; **, P < 0.01 (Student's t test).