Fig. 5.

LD structure of a 52-kb region spanning EPHX1 and extended promoter in European Americans. EPHX1 genotypes from HapMap (http://www.hapmap.org/) were downloaded, and the LD was determined using Haploview software. D′ values are displayed in the squares (empty squares have a pairwise D′ 1.00). Red squares show high pairwise LD, gradually coloring down to white squares of low pairwise LD. The black triangles indicate the haplotype blocks. There are three haplotype blocks in this region (one block in the large promoter region that spans into the first two exons of the gene, one block that spans exon 3 and nearby intronic regions, and one block that spans exons 4–9). At the upper portion gene structure region, red ovals indicate the coding polymorphisms in exons 3 (rs1051740) and 4 (rs2234922), which are not in LD with each other, nor with the promoter region.