TABLE 1.

Pharmacokinetic parameters of oxymorphone HCl (0.1 mg/kg s.c.) to healthy rhesus monkeys (n = 4)

Parameter	Units	Geometric Mean	Animal
			89040	AN96	AS60	AT62
AUCextrapolated	%	0.88	0.62	0.55	2.52	0.71
AUC0-last	h · ng · ml–1	45.08	50.10	64.69	38.20	33.35
AUC0-inf	h · ng · ml–1	45.58	50.41	65.05	39.19	33.59
AUMC0-inf	h · h · ng · ml–1	78.23	86.01	132.32	71.61	45.95
AUMC0-last	h · h · ng · ml–1	72.77	83.03	127.12	60.96	43.59
Cl · F–1	ml · min–1 · kg–1	32.54	29.42	22.80	37.85	44.15
Cmax	ng · ml–1	26.01	30.48	30.46	21.26	23.20
t1/2 λz	h	1.47	1.09	1.76	1.94	1.27
λz	h–1	0.47	0.64	0.39	0.36	0.55
MRT0-inf	h	1.72	1.71	2.03	1.83	1.37
MRT0-last	h	1.61	1.66	1.97	1.60	1.31
Tmax	h	0.50	0.50	0.50	0.50	0.50
Vz · F–1	liters · kg–1	4.15	2.78	3.47	6.36	4.85