TABLE 3.
Pharmacokinetic parameters of liposome encapsulated oxymorphone HCl 2 mg/kg s.c. to healthy rhesus monkeys Group 1 (n = 8) was sampled out to 144 h and group 2 (n = 2) was sampled out to 456 h.
|
Parameter
|
Units
|
Geometric Mean
|
Group 1 Animals
|
Group 2 Animals
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AQ96 | AS79 | AT13 | AT48 | AW57 | AX61 | AY60 | AZ36 | AP88 | AQ74 | |||
| AUCextrapolated | % | 48.49 | 45.77 | 37.12 | 61.05 | 54.01 | 28.43 | 75.83 | 50.35 | 50.22 | 10.86 | 2.74 |
| AUC0-last | h · ng · ml–1 | 201.81 | 98.11 | 299.78 | 215.08 | 124.36 | 178.74 | 228.46 | 566.97 | 151.04 | 210.94 | 231.85 |
| AUC0-inf | h · ng · ml–1 | 424.45 | 180.90 | 476.74 | 552.25 | 270.43 | 249.73 | 945.32 | 1141.88 | 303.42 | 236.63 | 238.37 |
| AUMC0-inf | h · h · ng · ml–1 | 81,317.40 | 33,889.23 | 64,545.36 | 116,387.11 | 51,381.27 | 26,943.43 | 440,437.75 | 195,577.93 | 62,975.84 | 47,242.81 | 60,150.91 |
| AUMC0-last | h · h · ng · ml–1 | 13,277.31 | 5041.46 | 20,275.01 | 15,923.12 | 6431.20 | 12,045.47 | 16,031.44 | 45,242.59 | 10,560.89 | 43,886.70 | 45,786.29 |
| Cl · F–1 | ml · min–1 | 69.89 | 164.00 | 62.23 | 53.72 | 109.70 | 118.80 | 31.38 | 25.98 | 97.77 | 124.46 | 125.37 |
| Cmax | ng · ml–1 | 12.78 | 19.35 | 20.30 | 5.26 | 11.89 | 14.16 | 12.70 | 20.41 | 7.90 | 9.17 | 12.32 |
| MRT0-inf | h | 191.58 | 187.34 | 135.39 | 210.75 | 190.00 | 107.89 | 465.91 | 171.28 | 207.55 | 198.19 | 254.20 |
| MRT0-last | h | 65.79 | 51.39 | 67.63 | 74.03 | 51.71 | 67.39 | 70.17 | 79.80 | 69.92 | 189.29 | 217.06 |
| Tmax | h | 0.57 | 0.25 | 0.50 | 1.00 | 1.00 | 1.50 | 1.00 | 0.25 | 0.25 | 0.50 | 0.50 |
| Vz · F–1 | liters · kg–1 | 672.03 | 2011.52 | 396.36 | 496.24 | 1235.75 | 469.40 | 843.63 | 183.16 | 1173.12 | 438.63 | 776.07 |