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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Feb 12;1793(7):1165–1173. doi: 10.1016/j.bbamcr.2009.02.001

Figure 7. High expression levels of TGFBR2 induce apoptosis in V-400R2 cells.

Figure 7

A. TGF-β mediated apoptosis was assessed using the Cell Death ELISA in V-400R2 treated with RG-115819 and TGF-β (10ng/ml). TGF-β mediated apoptosis is increased with doses of RG-115819 greater than 0.4 μM indicating that moderate-high levels of TGFBR2 and CDKN1A/p21 are needed for TGF-β to induce apoptosis in these cells. B. TGF-β mediated apoptosis assessed by caspase 3 and 7 activity confirms the results obtained with the Cell Death ELISA assay showing apoptosis directly correlates with TGFBR2 levels.