TABLE 2.
Clinical characteristics of study population across HOMA-IR quartile.
| Ethnicity | HOMA-IR quartile | P-value | |||
|---|---|---|---|---|---|
| Variables | 1 | 2 | 3 | 4 | for trend |
| Caucasians (n) | 79 | 74 | 80 | 84 | |
| Age (yrs) | 55.8±11.1 | 56.4±9.9 | 56.6±10.3 | 56.9±9.8 | NS |
| BMI (kg/m2) | 26.0±3.8 | 28.8±4.7 | 30.7±6.1 | 32.8±6.7 | <0.001 |
| Total cholesterol (mg/dl) | 196±40 | 201±43 | 198±42 | 201±40 | NS |
| LDL cholesterol (mg/dl) | 123±33 | 125±33 | 123±38 | 123±34 | NS |
| HDL cholesterol (mg/dl) | 43±13 | 42±11 | 41±13 | 36±10 | 0.002 |
| Triglyceride (mg/dl) | 128(100–192) | 143(115–205) | 162(112–206) | 202(134–305) | <0.001 |
| Glucose (mg/dl) | 96±10 | 108±26 | 130±46 | 177±87 | <0.001 |
| Insulin (µU/ml) | 7.3(6.5–8.6) | 11.7(10.5–13.0) | 17.4(15.8–20.2) | 38.4(29.9–61.9) | <0.001 |
| CRP (mg/L) | 1.8(0.9–3.7) | 3.0(1.2–6.8) | 2.9(1.6–8.4) | 4.5(2.3–13.8) | <0.001 |
| Fibrinogen (mg/dl) | 308±90 | 321±80 | 327±91 | 352±89 | 0.017 |
| Composite score | 8.6(1.4–22.8) | 10.3(0.0–23.3) | 12.9(3.1–30.4) | 18.5(4.3–32.6) | NS |
| African Americans (n) | 54 | 55 | 56 | 57 | |
| Age (yrs) | 53.1±10.3 | 54.8±8.9 | 54.2±9.7 | 56.3±9.1 | NS |
| BMI (kg/m2) | 24.4±4.7 | 27.5±6.0 | 30.4±5.5 | 31.2±5.9 | <0.001 |
| Total cholesterol (mg/dl) | 185±45 | 194±48 | 200±37 | 204±50 | NS |
| LDL cholesterol (mg/dl) | 111±36 | 124±46 | 130±31 | 133±49 | 0.032 |
| HDL cholesterol (mg/dl) | 55±23 | 48±15 | 47±15 | 47±13 | 0.038 |
| Triglyceride (mg/dl) | 87(72–118) | 105(85–134) | 106(83–146) | 119(83–163) | NS |
| Glucose (mg/dl) | 100±23 | 105±26 | 118±43 | 145±60 | <0.001 |
| Insulin (µU/ml) | 6.0(5.0–7.3) | 11.0(9.6–12.3) | 16.5(15.1–18.3) | 33.3(24.2–54.0) | <0.001 |
| CRP (mg/L) | 3.2(1.2–7.4) | 3.4(1.5–11.3) | 4.2(2.5–12.8) | 4.6(3.0–9.8) | NS |
| Fibrinogen (mg/dl) | 355±84 | 388±115 | 395±121 | 406±131 | NS |
| Composite score | 7.4(1.1–17.5) | 5.7(1.5–21.3) | 8.3(2.9–23.6) | 14.0(3.4–33.3) | NS |
NS, not significant. Data are means ± SD or for non-normally distributed variables as median (interquartile range). Group means were compared using Oneway ANOVA. Values for triglyceride, insulin, CRP and composite score, were logarithmically transformed before analyses. HOMA-IR quartiles for Caucasians were defined as: ≤1.24; 1.25–1.99; 2.00–3.49; ≥3.50, and for African Americans were ≤1.19; 1.20–1.89; 1.90–2.89; ≥2.90, respectively.