Table 2.
Results from multilocus test using GenoPDT with rs1411187 and rs6986303
Genotype | ||||||||
---|---|---|---|---|---|---|---|---|
rs1411187 | rs6986303 | Trans | NotTrans | Aff | Unaff | Z-score | p-valuea | Global Testa |
T,T | T,T | 12 | 8 | 6 | 3 | 1.58 | 1.14×10−1 | χ2=28.90, p=3.00×10−4 |
T,T | T,C | 81 | 43 | 29 | 14 | 3.21 | 1.00×10−3 | |
T,T | C,C | 74 | 91 | 36 | 24 | −1.17 | 2.42×10−1 | |
T,C | T,T | 30 | 17 | 14 | 9 | 1.37 | 1.72×10−1 | |
T,C | T,C | 136 | 123 | 66 | 33 | 1.88 | 6.00×10−2 | |
T,C | C,C | 157 | 167 | 59 | 43 | −1.17 | 2.42×10−1 | |
C,C | T,T | 15 | 13 | 6 | 2 | 0.79 | 4.31×10−1 | |
C,C | T,C | 55 | 83 | 15 | 16 | −2.79 | 5.00×10−3 | |
C,C | C,C | 66 | 81 | 23 | 22 | −1.79 | 7.30×10−2 |
Trans=transmitted; NotTrans=not transmitted; Aff=affected sib; Unaff=unaffected sib
There is 1 degree of freedom for the genotype specific tests, and 8 degrees of freedom for the global test