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(A) Endoscopic view of the rectum in patient 4 at 33 months of sulindac treatment revealing flat erythematous lesion. Mucosal biopsies revealed tubular adenoma and fibroinflammatory exudate. No polypoid adenomas were present. (B) Endoscopic view of the rectum at 35 months of sulindac treatment. Ulce rating rectal adenocarcinoma shown without concomitant re ctal polypoid adenomas.
