Table 1.

Prostaglandin Levels in Rectal Mucosal Biopsy Specimens^*

	Prostaglandin ng/mg protein			Baseline change (%)†
	Control	FAP	FAP & SUL
PGD2	1.541 ± 0.461	1.136 ± 0.182	0.729 ± 0.450c	−38.8
PGE2	5.355 ± 1.015	4.832 ± 0.454	2.930 ± 1.820bc	−32.3
PGF2a	3.345 ± 0.791	2.917 ± 0.881	1.618 ± 0.888bc	−43.6
TXB2	0.945 ± 0.042	1.673 ± 0.329a	1.005 ± 0.643b	−45.2
6KPGF1a	0.960 ± 0.482	1.184 ± 0.108	0.567 ± 0.307bc	−49.5

^*Results are mean ± SD. FAP is familial adenomatous polyposis; FAP & SUL is FAP patients treated with sulindac.

^aP = 0.016 FAP compared to control

^bP = 0.05 FAP compared with FAP treated with sulindac

^cP = 0.05 FAP treated with sulindac compared to control.

^†Percent change from baseline in patients before and after sulindac treatment.