Table 1.

Allele frequencies in candidate prostate cancer genes

Gene	Nucleotide Sequence Variant	Amino Acid Change	Allele Frequency (Total No. of Individuals)
			Asian-Indian		Black§		European-American§
			Controls	Cases	Controls	Cases	Controls	Cases
MSR1	−14,742 A>G	None	0.120 (230)	0.107 (112)	0.269 (130)‡	0.253 (93)	0.105 (343)	0.105 (530)
	−14,637 A>G	None	0.026 (227)	0.036 (112)	—	—	—	—
	IVS5 −59C>A	None	0.086 (234)	0.054 (111)	0.012 (123)‡	0.006 (85)	0.059 (314)	0.050 (484)
	IVS7 delinsTTA	None	0.174 (233)	0.183 (103)	0.264 (110)‡	0.218 (78)	0.057 (281)‡	0.045 (447)
	823 C>G	P275A	0.175 (240)	0.180 (111)	0.07 (333)|	0.05 (131)	0.06 (488)¶	0.06 (496)¶
	542 T>A†	I181K	0.039 (244)	0.040* (112)	—	—	—	—
RNASEL	1385G>A	R462Q	—	—	0.119 (126)	0.159 (88)	0.361 (321)	0.370 (505)
	1623 T>G	D541E	0.477 (242)	0.535 (113)	NT	NT	0.44 (508)**	0.45 (929)**

^*Deviations from Hardy-Weinberg proportions based on χ².

^†Previously unpublished missense variant.

^‡Significant difference in frequency compared with Asian-Indian controls.

^§Allele frequencies are based on Rennert et al.¹⁵ unless indicated otherwise:

^|Miller et al.,²⁴

^¶Wang et al.,²²

^**Wang et al,¹⁹ Li and Ti²⁰.