Table 1.
Parameters used to generate the surrogate data
| Parameters for which we used different values in simulations | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description | Notation | Units | Values used in simulations | ||||||
| Absorption rate of drug into blood | ka | day−1 | 0.19 | 2 | 7 | ||||
| Drug concentration that leads to 50% effectiveness | EC50 | μg/L | 0.01 | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 |
| Elimination rate of drug from blood. | ke | day−1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 |
| Hill coefficient | n | 1 | 3 | ||||||
Parameter values used in all the simulations: Virion clearance rate; c = 9.9 day−1: Infected cell loss rate; δ = 0.32 day−1: Initial viral load; V0 = 5.0 × 106 IU/mL: Total drug dose; D = 129.6 μg: Production rate of virus per infected cell; P = 10 virions day−1: Bioavailability of drug/volume of distribution; F/Vd = 0.01 L−1: Initial number of infected cells; I0 = cV0/p = 4.95 × 106: Number of target cells; T0 = 1.53 × 106 cell/mL: Infection rate constant; β = cδ/(T0p) = 1.0 × 10−7 IU−1 ml day−1: Initial concentration of drug at injection site; X0 = FD = 1.296 Vd μg/L: Initial concentration of drug in blood; A0 = 0 μg/L.