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Increased inflammatory cytokines in Rag-1 PD-1 DKO mice. B6 Rag-1KO (n = 3) and DKO (n = 3) mice were intravenously infected with 105 CFU LM. Sera were collected 0, 6, 12, and 24 hours after infection and pooled within each group. Serum (A) IL-12p70, (B) TNF-α, and (C) IFN-γ were determined by sandwich ELISA. Data shown are representative of 3 experiments. Error bars represent SD. *P < .05; **P < .01.
