Figure 8.
LXA4 fails to induce angiogenesis. C57BL/6 mice were injected subcutaneously with 0.5 mL of Matrigel premixed with vehicle or 5 μM 15(S)-HETE or 5 μM LXA4. One week later, the animals were killed and the Matrigel plugs were harvested from underneath the skin, and cryosections were either made and immunostained for CD31 using anti-CD31 antibodies or analyzed for hemoglobin content using Drabkin reagent. The values in the bar graph are the mean plus or minus SD of 6 plugs from 6 animals. *P < .01 versus vehicle control.