Effect of alegebrium on left ventricular mass (top panel) and tissue Doppler early diastolic velocity at the mitral annulus in older patients with diastolic heart failure. From Little WC, Zile MR, Kitzman DW, Hundley WG, O’Brien T.X., deGroof RC. The Effect of Alagebrium Chloride (ALT-711), a Novel Glucose Cross-Link Breaker, in the Treatment of Elderly Patients with Diastolic Heart Failure. J Card Fail 2005 5 A.D.; 11(3):191–195.