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. 2009 Apr 20;185(2):291–303. doi: 10.1083/jcb.200811105

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© 2009 Manzl et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — PIDD is dispensable for cell death induction in lymphocytes. Thymocytes derived from mice of the indicated genotypes were put in culture without further treatment (spontaneous cell death) or exposed to apoptosis inducers as indicated over time. Cell death was monitored by Annexin V–FITC/PI staining and flow cytometric analysis at the indicated time points. Data are means ± SD from four to eight independent experiments per genotype, with the exception of pidd^−/−puma^−/− (n = 2). The extent of apoptosis induced specifically by different stimuli was calculated by the equation (induced apoptosis − spontaneous cell death)/(100 − spontaneous cell death). No significant differences in cell death induction were observed between wild-type and PIDD- and caspase-2–deficient cells treated with any of the indicated stimuli by analysis of variance.