Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Apr 20;185(2):291–303. doi: 10.1083/jcb.200811105

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2009 Manzl et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 4. — Impact of PIDDosome loss on mitochondrial function and cytochrome c release. (A) Mitochondrial membrane potential was determined by JC-1 staining, and representative FACS blots of control and etoposide-treated SV40-immortalized MEFs are depicted. The bar graph shows quantification of FACS analysis using JC-1 staining of SV40-immortalized MEFs of the indicated genotypes 24 h after treatment. (B) Cytochrome c release was monitored in untreated or etoposide- or staurosporine-treated SV40-immortalized MEFs after 24 h by flow cytometric analysis. Representative FACS blots of control and etoposide-treated SV40-immortalized MEFs are depicted. The bars represent the percentage of cells that released cytochrome c. (A and B) The bar graphs represent the means ± SEM of n ≥ 3 independent experiments per genotype and treatment. *, P < 0.05 compared with wild type (wt).