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. 2009 Apr 20;185(2):357–370. doi: 10.1083/jcb.200809110

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© 2009 Chan et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Recruitment of active Src to focal adhesions but not invadopodia requires FAK. (A and B) MTLn3 cells transiently transfected with control siRNA (Ctlsi) or FAK siRNA (FAKsi) were cultured on fibronectin-gelatin coverslips and stained with anti-pY416 Src antibody (red) and anticortactin antibody (A, green) or antivinculin antibody (B, green). (A) Ratiometric images are presented as a ratio of cortactin/pY416 Src. (B) Ratiometric images are presented as a ratio of vinculin/pY416 Src. Regions outlined by boxes correspond to magnified images of pY416 Src localization at focal adhesions and invadopodia shown in insets. The color bars indicate the ratio on a scale of black = 0 (high pY416 Src) to white = 10 (low pY416 Src). Bars, 10 µm.