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. 2009 Apr 20;185(2):357–370. doi: 10.1083/jcb.200809110

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© 2009 Chan et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 9. — A model for FAK in invadopodia regulation. FAK and its phosphorylation at Tyr-397 recruit a pool of active Src to mediate localized tyrosine phosphorylation of substrates at focal adhesions. A balance between tyrosine phosphorylation at focal adhesions and invadopodia is required for proper dynamics and cell migration. Depletion of FAK releases active Src to mediate enhanced phosphorylation of substrates at invadopodia, which impairs focal adhesion dynamics but enhances the formation and dynamics of invadopodia; however, this is not sufficient for effective invasion.