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. 2009 May 4;185(3):397–407. doi: 10.1083/jcb.200903088

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© 2009 Perpelescu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Sequential establishment in two steps of centromeric CENP-A chromatin. (A) Timing cascade of centromere localization of hMis18, nascent CENP-A, and Rsf-1. Dark shade gradients represent gradual accumulation or loss of the indicated factor at centromeres throughout the cell cycle progression from anaphase to the synthetic phase. (B) Putative two-step model for CENP-A nucleosomes establishment at centromeres. Establishment of CENP-A nucleosomes at the centromere region occurs after a licensing process engaged by the Mis18 complex (1) in two sequences: first, loading of CENP-A occurs at or around centromere regions (2), followed by incorporation/assembly into the centromeric nucleosomes and spacing by RSF remodeling function (3).