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. 2000 Jul 11;97(15):8658–8663. doi: 10.1073/pnas.140210697

Figure 4.

Figure 4

FGF-induced resistance to cell kill by drugs. Drug-induced cell death in PC3 cells was monitored by the activity of LDH released to the culture medium. Results are expressed as a ratio of treated samples to untreated controls. Values for control samples varied by less than 10%. (Top to Bottom) Without CM or FGF (○); 0.9 ng/ml r-aFGF (▾, overlaps with the top control curve); 0.9 ng/ml r-bFGF (●); 0.16 ng/ml r-aFGF plus 0.9 ng/ml r-bFGF (⧫); CM of lung tumor histocultures (□); 0.9 ng/ml r-aFGF plus 0.9 ng/ml r-bFGF (■). Similar results were found for doxorubicin (shown here), paclitaxel, and 5-fluorouracil.