Table 3.

Reversal of FGF-induced resistance by suramin

Drug	Drug concentration required to produce 50% inhibition
	Control, no FGF		+ 0.3 ng/ml r-aFGF & 1 ng/ml r-bFGF
	No suramin	Suramin, 15 μM	No suramin	Suramin, 15 μM
Paclitaxel, nM	2.15  ± 0.25	2.14  ± 0.30	7.05  ± 2.61*	1.89  ± 0.30
Doxorubicin, nM	27.3  ± 2.8	35.7  ± 4.2	145  ± 33*	29.7  ± 3.7
5-Fluorouracil, μM	2.20  ± 0.39	2.43  ± 0.43	5.05  ± 1.17*	2.19  ± 0.40

Human PC3 cells were treated with drugs, with or without suramin and/or a combination of aFGF and bFGF. Drug activity was measured by the sulforhodamine B assay, which measures the cellular protein content. This assay gives higher IC₅₀ values compared with the BrdUrd incorporation assay. Mean ± SD. *, P < 0.05 compared with controls without FGF treatments (one way ANOVA).