Table 1.
The reintroduction schedule of antituberculous drugs in present case report
| Days | Drug given | Appearance of psychotic symptoms |
|---|---|---|
| Day 1 | Ethambutol 300 mg | No |
| Day 2 | Ethambutol 600 mg | No |
| Day 3 | Ethambutol 800 mg | No |
| Day 4 | Rifampicin 150 mg + ethambutol 800 mg | No |
| Day 5 | Rifampicin 300 mg + ethambutol 800 mg | Appearance of psychotic symptoms |
| Day 6 | All drugs stopped | Psychotic symptoms persisted |
| Day 7 | All drugs stopped | Psychotic symptoms resolved |
| Day 8 | Ethambutol 300 mg | No |
| Day 9 | Ethambutol 600 mg | |
| Thus, the ethambutol could be proved to be the responsible for the causation of the psychotic symptoms and could not be reintroduced. | Appearance of psychotic symptoms | |
| Day 10 | All drugs stopped till the resolutions of psychotic symptoms. | Psychotic symptoms persisted |
| Day 11 | No ATT given | Psychotic symptoms resolved |
| Day 12 | Rifampicin 150 mg | No |
| Day 13 | Rifampicin 300 mg | No |
| Day 14 | Rifampicin 450 mg | No |
| Day 15 | Rifampicin 450 mg+ pyrazinamide 250mg | No |
| Day 16 | Rifampicin 450 mg+ pyrazinamide 500mg | No |
| Day 17 | Rifampicin 450 mg+ pyrazinamide 1500mg | No |
| Day 18 | Day 16 regimen + isoniazid 50 mg | No |
| Day 19 | Day 16 regimen + isoniazid 300 mg | |
| Thus, isoniazid was also proved to be responsible for the causation of the psychotic symptoms and could not be reintroduced. | Appearance of psychotic symptoms again | |
| Day 20 | Day 16 regimen | Psychotic symptoms persisted |
| Day 21 | Day 16 regimen continued | Psychotic symptoms resolved |