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Effect of MgATP and ATP alone on CFTR-K1250A and -K464A. (A) Macroscopic current measurements were made in the presence of either 0 or 4 mM Mg2+, membrane potential was −80 mV, n = 4. Current with MgATP is shown as 100%. *, P < 0.05 compared with MgATP. (B) Example of single-channel traces. (C) Burst duration, n = 4. *, P < 0.01 compared with MgATP.
