Table 2.
Retention time and estrogenic response of indicative compounds
| Compound | Rt | MOEC | RPP | |
| μM | RPE ± SD | |||
| Endogenous compounds | ||||
| Cholesterol | 1.83 | 0.0001–10 | Nonactive | - |
| 5α-dihydroprogesterone | 4.14 | 10 | 58 ± 3 | 0.01 |
| Progesterone | 5.03 | 25 | 16 ± 2 | 0.004 |
| Pregnenolone | 6.07 | 10 | 92 ± 6 | 0.01 |
| Androsterone | 6.21 | 10 | 97 ± 3 | 0.01 |
| 5α-dihydrotestosterone | 6.63 | 1 | 64 ± 5 | 0.1 |
| Androstenedione | 6.80 | 10 | 16 ± 2 | 0.01 |
| Dehydroepiandrosterone | 6.86 | 1 | 92 ± 2 | 0.1 |
| Testosterone | 8.23 | 10 | 34 ± 5 | 0.01 |
| Estrone | 9.06 | 0.01 | 84 ± 8 | 10 |
| 17α-hydroxyprogesterone | 9.23 | 10 | 7 ± 1 | 0.01 |
| 17α-hydroxypregnenolone | 12.78 | 10 | 30 ± 1 | 0.01 |
| 17β-estradiol | 14.83 | 0.001 | 100 ± 7 | 100 |
| 16α-hydroxyestrone | 22.86 | 0.01 | 77 ± 2 | 10 |
| Estriol | 24.01 | 0.01 | 103 ± 3 | 10 |
| Organochlorines | ||||
| Hexachlorobenzene | 1.34 | 0.001 – 50 | Nonactive | - |
| PCB180 | 1.40 | 0.001 – 50 | Nonactive | - |
| p,p'-DDE | 1.43 | 12.5 | 92 ± 2 | 0.008 |
| PCB153 | 1.48 | 0.001 – 50 | Nonactive | - |
| PCB138 | 1.49 | 0.001 – 50 | Nonactive | - |
| o,p'-DDT | 1.53 | 6.25 | 96 ± 7 | 0.016 |
| Dieldrin | 1.75 | 25 | 44 ± 9 | 0.004 |
| Methoxychlor | 2.29 + 2.88 | 12.5 | 57 ± 8 | 0.008 |
| 4-OH-CB146 | 2.67 | 0.001 – 50 | Nonactive | - |
| 4-OH-CB187 | 2.67 | 50 | 24 ± 4 | 0.002 |
| 4-OH-CB107 | 2.70 | 0.001 – 50 | Nonactive | - |
| β-hexachlorocyclohexane | 4.13 | 2.5 | 61 ± 2 | 0.04 |
Abbreviations: Rt, retention time; MOEC, maximum observed effect concentration; RPE, relative proliferative effect; RPP, relative proliferative potency