Table 1.

Angiogenesis modulating biomarker status in various prostate archival specimens. (n= 42)

Antigen	BPH	Atrophy	PIN	MD PCa	PD PCa	Stroma
Annexin II	+(3)	++(4)*	++(2)*	-(4)	-(3)	+(4)
Cyclooxygenase-2	+(4)	+(4)	++(3)*	+(2)	+(1)	++(2)*
Decorin	-(4)	-(4)	++(2)*	-(4)	-(4)	+++(4)*
Versican	++(4)	+ (4)	+(2)	+ (3)	++(1)	+(3)
CD34	-(4)	+(4)	++(3)*	+(1)	++(3)*	ND

$ Benign Prostatic Hyperplasia (BPH), high-grade Prostatic Intraepithelial Neoplasia (PIN), moderately-differentiated prostate adenocarcinoma (MD PCa), poorly-differentiated prostate adenocarcinoma (PD PCa), not determined (ND). Staining Intensity was scored as negative(-), weak (+), moderate (++) or strong (+++). Average percentage of cells were estimated and placed empirically into four categories 1–25%, 26–50%, 51–75%, or 75–100% and denoted in parenthesis as (1), (2), (3) or (4) respectively. The combination factor (product) of staining intensity and percentage of cells was used for statistical significance analysis of the data. Significant correlation is denoted as '*' for p ≤ 0.05. The 95 % confidence limits for correlation coefficient were negative for Anx-II (0.015) and positive for COX-2 (0.019) expression in PCa.