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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: J Child Neurol. 2009 Feb 18;24(4):400–405. doi: 10.1177/0883073808324538

Table 3. Secondary treatment regimens and outcomes.

Initial Treatment Additional Treatments Highest Dose Additional
Treatment
Prescribed
(months
after initial
treatment)		 Permanent
Remission
(months
after initial
treatment)
ACTH Vigabatrin 157 mg/kg/day 1 1
ACTH Topirimate, Vigabatrin 25.7 mg/kg/day, 109.6 mg/kg/day 3.5, 5 6
ACTH Topirimate, Vigabatrin 27.9 mg/kg/day, 104.6 mg/kg/day 2, 3
ACTH Topirimate 30 mg/kg/day 3
ACTH None
ACTH Topirimate, Vigabatrin 46.8 mg/kg/day, 166 mg/kg/day 2.5, 5
ACTH None
ACTH None
ACTH Topirimate 14 mg/kg/day 6.5
ACTH Vigabatrin 133 mg/kg/day 20 20
ACTH Topirimate 4.5 mg/kg/day 1 2
ACTH Topirimate, Vigabatrin 10 mg/kg/day, 143 mg/kg/day 7, 17
Topirimate ACTH 220U/M2/day 3
Topirimate ACTH 150U/M2/day 3 8
Topirimate None
Topirimate None
Topirimate None
Topirimate None
Topirimate None
Topirimate Ketogenic Diet 16 18
Topirimate ACTH 260U/M2/day 1
Topirimate ACTH 140U/M2/day 0.5
Topirimate ACTH, Vigabatrin 80U/M2/day, 37 mg/kg/day 1, 37
Topirimate None
Topirimate ACTH, Vigabatrin 140U/M2/day, 18 mg/kg/day 2, 2
Topirimate None
Topirimate None
Topirimate ACTH 160U/M2/day 1 3
Topirimate None
Topirimate None
Topirimate None
Topirimate Vigabatrin 90 mg/kg/day 10