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NF-κB mediated gene expression. With hyperoxia, there is phosphorylation (p) of the inhibitory protein IκBα on tyrosine 42. This results in the ubiquination (u) and subsequent degradation of IκBα. This allows for dissociation and nuclear translocation of the active NF-κB complex (p65 and p50 are represented here), binding to consensus sequences on various genes and transcriptional activation or repression of gene expression.
