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LPS-induced serum S-SMase activity partially depends on ICE, an enzyme involved in IL-1 secretion. Wild-type (wt) and ICE knockout (KO) mice were injected i.p. with 50 mg/kg LPS or saline as control, and 3 h later serum was assayed for SMase activity in the presence of Zn2+. There were seven mice in each group. A significant difference (P < 0.01) was found between the following groups: LPS vs. saline (both in wild-type and ICE knockout mice) and LPS ICE knockout vs. LPS wild type.
