Table 1.
Genes of molybdenum cofactor biosynthesis in G. sulfurreducens and G. metallireducens.
| Locus | Gene in G. sulfurreducens | Gene in G. metallireducens | Function |
|---|---|---|---|
| modE | GSU2964 | Gmet_05111 | regulation of molybdate-responsive genes |
| modD | GSU2963 | none | inner membrane protein, possible quinolinate phosphoribosyltransferase |
| modA | GSU2962 | Gmet_0512 | molybdate transport (periplasmic component) |
| modB | GSU2961 | Gmet_0513 | molybdate transport (membrane component) |
| modC | GSU2960 | Gmet_0514 | molybdate transport (ATP-binding component) |
| moaD | none | Gmet_1044 | dithiolene addition to molybdopterin (molybdopterin synthase small subunit) |
| moeB | none | Gmet_1043 | molybdopterin synthase sulfurylase |
| moaE | GSU2699 | none | dithiolene addition to molybdopterin (molybdopterin synthase large subunit) |
| moeA | GSU2703 | Gmet_1038; Gmet_0336; Gmet_1804 | molybdenum-sulfur ligation? |
| moaC | GSU2704 | Gmet_1037 | molybdopterin precursor Z synthesis |
| moaB | GSU2705 | Gmet_1036 | molybdopterin precursor Z synthesis |
| mobA | GSU3147 N-terminal domain | Gmet_0300 N-terminal domain | attachment of molybdopterin to guanosine |
| mobB | GSU3147 C-terminal domain | Gmet_0300 C-terminal domain | attachment of molybdopterin to guanosine |
| moaA | GSU3146 | Gmet_0301; Gmet_0337; Gmet_2095 | molybdopterin precursor Z synthesis |
| mosC | GSU3145 | Gmet_0302; Gmet_2094 | molybdenum sulfurase |
| pcmV | none | Gmet_2138 | possible 4-hydroxybenzoyl-CoA reductase molybdenum cofactor biosynthesis protein |
| pcmW | none | Gmet_2139 | possible 4-hydroxybenzoyl-CoA reductase molybdenum cofactor biosynthesis protein |
| pcmX | none | Gmet_2140 | uncharacterized protein related to MobA |
1Gmet_0511 is missing the N-terminal ModE domain but retains the C-terminal molybdopterin-binding MopI domains.