Table 3.
Genotype and minor allele frequencies in myocardial infarction cases (n = 312) and controls (n = 317) of the SIPLAC study (Belfast and Glasgow pooled, UK)
| Genotype frequency (%) | p value adjusted for center | Minor allele frequency | ||||
|---|---|---|---|---|---|---|
| 11 | 12 | 22 | ||||
| T-512C | Cases | 36.2% | 48.3% | 15.5% | 0.40 | |
| Controls | 41.8% | 46.6% | 11.6% | 0.31 | 0.35 | |
| T-123/in1C | Cases | 61.0% | 34.2% | 4.8% | 0.22 | |
| Controls | 57.6% | 35.5% | 6.9% | 0.55 | 0.25 | |
| G-80/in1Aa | Cases | 54.9% | 38.5% | 6.6% | 0.26 | |
| Controls | 49.3% | 41.5% | 9.2% | 0.40 | 0.30 | |
| R38C | Cases | 97.0% | 3.0% | 0.0% | 0.02 | |
| Controls | 95.2% | 4.8% | 0.0% | 0.30 | 0.02 | |
| C+264A | Cases | 87.5% | 12.1% | 0.4% | 0.06 | |
| Controls | 89.3% | 10.3% | 0.4% | 0.82 | 0.06 | |
| G+303C | Cases | 92.1% | 7.9% | 0.0% | 0.04 | |
| Controls | 92.3% | 7.7% | 0.0% | 0.97 | 0.04 | |
11 homozygotes for the major allele, 12 heterozygotes, 22 homozygotes for the minor allele
aNearly complete concordance with T-123/in1C (85% of subjects concordant for the 2 polymorphisms)