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. 2009 Jun 9;106(25):10272–10277. doi: 10.1073/pnas.0811273106

Fig. 1.

Fig. 1.

Cytokine production capacity in individuals screened for the TIRAP S180L polymorphism. (A–D)Serum concentrations of proinflammatory cytokines TNF, IFN-γ, IL-6 (A–C) and the anti-inflammatory cytokine IL-10 (D) after 2 ng/kg LPS injection. Concentrations are given as mean (pg/mL) and SD for TIRAP S180 homozygous (SS, n = 14) and S180L heterozygous (SL, n = 6) individuals. (E) To study the effect of the TIRAP 180L polymorphism on other TLRs, PBMCs were stimulated with TLR2 (10 μg/mL Pam3Cys), TLR4 (10 ng/mL LPS), and TLR9 (25 μg/mL CpG) ligands. (F) IFN-α release by PBMC of patients with or without polymorphisms was also assessed. Concentrations are given as mean (pg/mL) and SEM for TIRAP S180 homozygous (SS, n = 4), S180L heterozygous (SL, n = 5) individuals, and one 180L homozygous individual. *, P = 0.05; **, P = 0.01; ***, P = 0.001 (Mann-Whitney U test).