Table 1.
Clinical characteristics of 160 patients with VAP and sepsis enrolled in the study
| Characteristics | SS | SL | LL |
|---|---|---|---|
| n (Male/female) | 121 (91/30) | 43 (31/12) | 2 (2/0) |
| Age in years, mean ± SD | 61.4 ± 18.1 | 55.9 ± 12.2 | 48.5 ± 27.6 |
| CPIS, mean ± SD* | 7.76 ± 1.11 | 7.74 ± 1.31 | 9.50 ± 0.70 |
| SAPS II score, mean ± SD | 38.8 ± 13.8 | 37.4 ± 13.5 | 39.0 ± 0 |
| White blood cells per mL, mean ± SD | 13,312.1 ± 7,013.4 | 12,809.8 ± 4,921.8 | 10,030.1 ± 5,600.3 |
| Septic shock: no (%)† | 65 (53.7) | 25 (58.1) | 1 (50?) |
| Septic shock: yes (%)† | 56 (46.3) | 18 (41.9) | 1 (50) |
| pO2/FiO2, mean ± SD | 226.1 ± 117.1 | 222.3 ± 100.2 | 190.5 ± 13.4 |
Polymorphism between genotypes are in Hardy–Weinberg equilibrium. SS, wild type, i.e. patients without Mal mutations; SL, mutant Mal, i.e. patients carrying the Ser180Leu SNP; LL, homozygous mutants, i.e., patines only carrying the 180Leu SNP; CPIS, clinical pulmonary infection score. pO2/FiO2 ratios are given as an index of the oxygentation.
*P = 0.038 between WT and homozygotes; P = 0.039 between heterozygotes and homozygotes (P values after Bonferroni correction).
†Total numbers of patients in the subgroups comparing patients with and without septic shock. There were no differences between groups.