Table 1.

Monoamines and their metabolites, GABA, and glutamate levels in the brains of Tph2-deficient mice

	5-HT (pg)	5-HIAA (pg)	NA (pg)	Glutamate (pmol)	GABA (pmol)	DA (pg)	DOPAC (pg)	HVA (pg)
Control	710.1 ± 56.9	147.4 ± 13.2	419.6 ± 17.2	10.2 ± 0.5	2.93 ± 0.09	1116.4 ± 32.8	119.6 ± 4.2	147.3 ± 12.3
Tph2−/−	28.4 ± 3.6***	ND	395.7 ± 23.9	10.1 ± 0.6	2.80 ± 0.04	1139.4 ± 27.6	121.1 ± 12.7	156.4 ± 10.5

Serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), norephinephrine (NA), Glutamate, γ-aminobutyric acid (GABA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) levels were measured in whole brain lysates per milligram of wet tissue of Tph2^−/− (n = 4) and control (n = 6) mice (mixed background). Data are presented as mean ± SEM; ND, not detectable. ***, P < 0.001 vs. control group, 1-way ANOVA, followed by Tukey's post hoc test.