Table 1.
Age and Plasma Homocysteine Levels in Framingham Offspring Undergoing MRI.
| Age at Exam (years) |
Plasma tHcy at 5th Offspring Examination (mean and range in μmol/L) |
Plasma tHcy at 7th Offspring Examination (mean and range in μmol/L) |
||||||
|---|---|---|---|---|---|---|---|---|
| N at exams 5 and 7 |
Q1 | Q2 | Q3 | Q4 | Q1 | Q2 | Q3 | Q4 |
| <40 (n= 101 and 0) |
5.9 4.0-7.6 |
7.6 5.8-8.8 |
9.5 8.1-11.0 |
13.6 10.9-26.4 |
||||
| 40-49 (n= 481 and 219 ) |
6.3 4.0-8.3 |
8.2 6.6-10.0 |
9.8 8.3-11.4 |
13.4 9.1-45.0 |
5.3 3.6-6.7* |
6.6 5.7-7.7* |
7.7 6.6-9.0* |
11.8 7.7-92.6* |
| 50-59 (n= 543 and 708) |
6.4 3.9-8.5 |
8.4 7.0-10.1 |
10.1 8.3-11.9 |
14.8 10.6-97.1 |
5.6 3.3-7.3 |
7.0 5.8-8.3 |
8.1 6.8-9.8 |
11.0 8.1-65.2 |
| 60-69 (n= 464 and 590) |
6.8 4.3-8.3 |
8.7 7.4-10.2 |
10.6 8.9-12.4 |
14.8 11.1-35.0 |
5.8 3.3-7.2 |
7.4 6.2-8.8 |
8.9 7.6-10.7 |
11.9 9.2-28.9 |
| 70+ (n= 74 and 406) |
7.4 5.4-8.9 |
9.6 8.6-11.2 |
11.4 10.2-12.5 |
13.7 11.9-16.8 |
6.2 4.0-7.7 |
7.8 6.7-9.2 |
9.3 8.0-10.9 |
12.9 10.-37.2 |
| All ages (n= 1663 and 1923) |
6.5 3.9-8.9 |
8.4 5.8-11.2 |
10.2 8.1-12.5 |
14.3 9.9-97.1 |
5.8 3.3-7.7 |
7.2 5.7-9.2 |
8.6 6.6-92.6 |
11.8 7.7-92.6 |
*
age group <50 years at the time of MRI
†
tHcy values in adjacent quartiles overlap since the range of values with in each quartile differed in men and women.
‡
Number of subjects at this age range at time of MRI who had plasma tHcy measurements available at 5th and 7th Offspring examinations respectively