Table 2.
Description of Stroke Risk Factors (Prevalence and Levels) and Other Covariates in Subjects Grouped By Quartile Of Baseline Plasma Homocysteine Level.
| 5th Offspring Examination | 7th Offspring Examination | |||||
|---|---|---|---|---|---|---|
| Q1-Q3 | Q4 | P value | Q1-Q3 | Q4 | P value | |
| Framingham Stroke Risk Profile Variables |
N-1247 | N=416 | N=1442 | N=481 | ||
| Age (in years)* | 54 ± 10 | 55 ± 10 | 0.598 | 61 ± 9 | 61 ± 9 | 0.705 |
| Systolic Blood Pressure (mmHg) * |
124 ± 18 | 125 ± 19 | 0.375 | 125 ± 18 | 127 ± 20 | 0.046 |
| Treatment with antihypertensive medication (%) |
14.3% | 19.1% | 0.020 | 28.0% | 37.6% | <0.001 |
| Diabetes (%) | 5.1% | 4.6% | 0.647. | 7.7% | 11.7% | 0.008 |
| Current Smoker (%) | 13.1% | 25.8% | <0.001 | 10.8% | 15.2% | 0.010 |
| History of cardiovascular disease (%) |
5.5% | 7.5% | 0.136 | 8.0% | 12.9% | 0.001 |
| Atrial fibrillation (%) | 1.0% | 1.2% | 0.786 | 2.8% | 3.7% | 0.322 |
| ECG-LVH (%) | 1.7% | 2.7% | 0.209 | 1.8% | 2.3% | 0.435 |
| FSRP Score* | 4.0 ± 4.7 | 4.5 ± 5.5 | 0.069 | 6.3 ± 7.3 | 7.6 ± 8.9 | 0.005 |
| Other Covariates | ||||||
| Education: High school graduate (%) |
96.5% | 96.0% | 0.654 | 96.9% | 95.3% | 0.106 |
| Folate level (ng/ml) | 9 ± 6 | 5 ± 4 | <0.001 | |||
| Vitamin B12 level (pg/ml)* | 470 ± 241 | 390 ± 234 | <0.001 | |||
| Vitamin B12 < 150 | 4.5% | 6.4% | 0.151 | |||
| Pyridoxal 5′-phosphate level (nmol/ml)* |
80 ± 65 | 61 ± 48 | <0.001 | |||
| Serum creatinine (mg/dl)* | 1.0 ± 0.2 | 1.1 ± 0.2 | 0.004 | |||
| Body Mass Index (kg/m2)* | 27 ± 5 | 28 ± 5 | 0.091 | 28 ± 5 | 29 ± 5 | 0.001 |
| Plasma cholesterol (mg/dl)* | 203 ± 36 | 207 ± 39 | 0.069 | 200 ± 36 | 202 ± 39 | 0.475 |
| Apolipoprotein genotype: ε4 +ve (%) |
23.6% | 20.9% | 0.256 | 22.6% | 22.0% | 0.796 |
| Any Alcohol Use | 72.3% | 68.7% | 0.158 | 67.0% | 66.2% | 0.744 |
*
: Mean ± SD