Table 3.
Results of Multivariable Regression Analyses of Plasma Homocysteine (tHcy) levels at the 5th and 7th Offspring Examination on Primary MRIV ariables: Total Cerebral Brain Volume (TCBV), Risk Of Extensive White Matter Hyperintensity On Brain MRI (WMH) And Risk Of Silent Cerebral Infarcts (SCI) — analyses using different measures of tHcy
| Outcome variable* |
Observed value in entire group |
per log elevation of tHcy | Quartiles of homocysteine (age-specific) | p (trend across quartiles) |
Q4 vs. Q1-3; change and p value |
||||
|---|---|---|---|---|---|---|---|---|---|
| Change | p | Q1 | Q2 | Q3 | Q4 | ||||
| Plasma homocysteine (tHcy) measure at 5th Offspring Examination (N=1663) | |||||||||
| TCBV | Mean ± SD: 77.8 ± 3.2 |
β= -0.40 | 0.05 | 77.9 | 77.9 | 77.9 | 77.5 | 0.08 | β= -0.38; p= 0.01 |
| (adjusted means ± SE) | |||||||||
|
Extensive WMHI (%) |
12.2% | OR: 1.06 | 0.81 | 1.00 | 1.23 | 1.05 | 1.10 | 0.85 | OR: 1.01; p= 0.96 |
| SCI (%) | 11.2% | OR: 1.72 | 0.03 | 1.00 | 0.98 | 1.25 | 1.60 | 0.02 | OR: 1.49; p= 0.02 |
| Plasma homocysteine (tHcy) measure at 7th Offspring Examination (N =1923) | |||||||||
| TCBV | Mean ± SD: 77.9 ± 3.2 |
β= -0.68 | 0.001 | 78.0 | 78.2 | 78.0 | 77.6 | 0.004 | β= -0.489; p<0.001 |
| (adjusted means ± SE) | |||||||||
|
Extensive WMHI (%) |
12.4% | OR: 0.98 | 0.92 | 1.00 | 0.73 | 0.80 | 0.87 | 0.58 | OR: 1.04; p=0.82 |
| SCI (%) | 11.2% | OR: 1.42 | 0.16 | 1.00 | 1.34 | 1.29 | 1.51 | 0.08 | OR; 1.25 ; p=0.17 |
*
All analyses are adjusted for age, gender, and interval between the baseline examination and date of brain MRI; TCBV is addit ionally adjusted for age-squared.