. Author manuscript; available in PMC: 2009 Jun 23.

Published in final edited form as: Arch Neurol. 2008 May;65(5):642–649. doi: 10.1001/archneur.65.5.642

Table 6.

Results Of Multivariable Regression Analyses Of Plasma homocysteine (tHcy) levels on Secondary MRI Measures

	5^th Offspring Examination			7^th Offspring Examination
Predictor variable^*	Mean ± SD	Q4 vs. Q1-3 Change	P value	Mean ± SD	Q4 vs. Q1-3 Change	P value
Frontal Brain Volume	35.6 ± 3.3	-0.07	0.160	35.6 ± 3.3	-0.14	0.001
Occipital Brain Volume	10.4 ± 2.8	-0.02	0.731	10.4 ± 2.7	0.01	0.901
Parietal Brain Volume	21.5 ± 3.5	-0.03	0.631	21.6 ± 3.5	0.02	0.722
Temporal Brain Volume	10.4 ± 0.9	-0.01	0.924	10.4 ± 0.9	-0.10	0.037
Hippocampal Volume (n=661)	0.31 ± 0.04	-0.11	0.192	0.31 ± 0.04	-0.15	0.065

All analyses are adjusted for age, age squared, gender, and tim e between Offspring examination and MRI; Frontal, occipital, parietal, temporal and hippocampal brain volumes are all expressed in standard deviation units.